Chronic inflammatory demyelinating polyneuropathy after allogeneic hematopoietic stem cell transplantation: a case report and review of the literature
10.3760/cma.j.issn.1009-9921.2011.11.009
- VernacularTitle:异基因造血干细胞移植后慢性炎症性脱髓鞘性多发神经病变一例并文献复习
- Author:
Kai HU
;
Jijun WANG
;
Wei WAN
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Chronic inflammatory demyelinatingpolyneuropathy;
Graft-versus-host disease
- From:
Journal of Leukemia & Lymphoma
2011;20(11):669-671
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study chronic inflammatory demyelinating polyneuropathy(CIDP)after allogeneic hematopoietic stem cell transplantation(allo-HSCT)and the clinical manifestation,diagnosis and treatment.MethodsThe clinical manifestation,laboratory examination,treatment and outcome of a patient with chronic myeloid leukemia after allo-HSCT were studied.ResultsAcute and chronic graft-versus-host disease(GVHD) were occurred in the patient followed by chronic multiple nervous system symptoms from +105 day including facioplegia,decreased muscle strength and dysuria.According to clinical manifestation,results of cerebrospinal fluid exam and electroneurophysiology exam,CIDP was diagnosed.The clinical condition was improved after treatment with intravenous immunoglobulin,glucocorticoid, immunosuppressive agents and functional exercises,but the patient died of secondary infection finally.ConclusionCIDP after allo-HSCT is a rare complication of nervous system and difficult to diagnose and treat.Numerous transplant-related causes are probably associated with the development of CIDP.The main causes are GVHD and immune dysfunction.Early accurate diagnosis and rational treatment is of great importance.
