Current study of hypercoagnlability in multiple myeloma
10.3760/cma.j.issn.1009-9921.2011.11.018
- VernacularTitle:多发性骨髓瘤高凝状态的研究现状
- Author:
Yang ZHOU
;
Lihong LI
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Thrombosis;
Endothelium,vascular;
Blood coagulation
- From:
Journal of Leukemia & Lymphoma
2011;20(11):691-694
- CountryChina
- Language:Chinese
-
Abstract:
Mutiple myeloma(MM)has been associated with the hypercoagulable states and the development of venous thromboembolic events(VTE). Described pathogenetic mechanisms that are not exclusive to MM include the abnormality of blood clotting components,the dysfunction of fibrinolysis,the disorder of platelets,the abnormity of blood stream and blood viscosity,etc..It has been proved that high levels of vascular endothelial growth factor (VEGF),von Willebrand factor (vWF),increased production of inflammatory cytokines and higher expression of COX-2 in MM seem to be associated with the hypercoagulability. In addition, the treatment of MM may also result in the treatment-associated hypercoagulable states.
