Research progress of CD+4 CD+25 Foxp3 Treg cells in the hematological malignancies
10.3760/cma.j.issn.1009-9921.2008.03.028
- VernacularTitle:调节性T细胞在血液系统恶性肿瘤中的研究进展
- Author:
Liang SHAO
;
You ZHANG
- Publication Type:Journal Article
- Keywords:
Hematologic neoplasms;
T-lymphocytes,regulatory;
Gytotoxicity,immunologic;
Hemic and immune systems
- From:
Journal of Leukemia & Lymphoma
2008;17(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Thymus derived CD+4; CD+25 regulatory T cells (Treg) are thought to be specific T cells that play an important role in controlling autoimmunity, preventing transplant rejection, restraining anti-infectious immune response, suppressing allogeneic immune respons. More recently, these cells are reported to have the ability of suppressing antitumor immune response. Foxp3 are the most specific protein of Treg. In this review, we will discuss the expression of CD+4 CD+25 Treg in patients with hematological malignancies and its implication for immunotherapy.
