Inhibitory effect of CT-guided percutaneous high-temperature pingyangmycin lipiodol injection on VX2 tumors of rabbit
- VernacularTitle:CT引导下经皮注射高温平阳霉素超液化碘油对兔VX2肿瘤的抑瘤效果
- Author:
Xuefeng WANG
;
Maoheng ZU
- Publication Type:Journal Article
- Keywords:
Rabbits;
VX2 tumor;
Lipiodol;
CT-guided;
Pingyangmycin
- From:
Chinese Journal of Interventional Imaging and Therapy
2009;6(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the inhibitory effect on the VX2 tumor of rabbit with CT-guided percutaneous high-temperature pingyangmycin lipiodol injecting. Methods New Zealand white rabbits were performed to plant rabbit VX2 tumor in the left liver leaf. After two weeks, all the rabbits were scanned with CT and divided into 5 groups randomly, and every group was injected different temperature pingyangmycin combined with lipiodol, then the effect was evaluated after 2 weeks. Results Compared with control group, the volume of VX2 tumor in every group injected high-temperature lipiodol reduced obviously (P<0.05), and the necrosis rate of hepatic transplant tumor increased significantly (P<0.05) as the temperature increased. MVD value of the tumor and VEGF expression obviously reduced (P<0.05), there was a positive relationship between MVD value and VEGF expression with the temperature. Conclusion CT-guided percutaneous high-temperature pingyangmycin lipiodol injecting can inhibit the VX2 tumor growth and tumor angiogenesis formation obviously, and the higher temperature, the better the therapeutic effect.
