Analysis on curative effects of multiple myeloma using small dose of thalidomide and chemotherapy
10.3760/cma.j.issn.1009-9921.2008.05.014
- VernacularTitle:小剂量沙利度胺联合COMP方案治疗多发性骨髓瘤的疗效分析
- Author:
Aili HE
;
Wanggang ZHANG
;
Yun YANG
;
Xingmei CAO
;
Jianli WANG
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Drug therapy,combination;
Thalidomide
- From:Journal of Leukemia & Lymphoma
2008;17(5):356-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the curative effects and adverse effects of the thalidomide combined with COMP chemotherapy in treating multiple myeloma(MM).Methods 42 patients were initially diagnosed as MM and 27 patients were refractory and relapsed MM.The small dose of thalidomide combined with COMP management and COMP management alone were used.The effective rate and adverse effects were analyzed.Changes of M-protein in serum,percentage of plasma cells in bone marrow and the level of hemoglobin were also analyzed in both pre-treatment and post-treatment periods.Results In 42 patients who were initially diagnosed as MM,the effective rate was 40.9% for 22 patients treated by chemotherapy alone and 70.0% for 20 patients treated by the thalidomide combined with chemotherapy.Statistic difference was observed between those two group.As to the 27 patients who were refractory and relapsed MM,the effective rate was 42.9% for 13 patients treated by chemotherapy alone and 84.6% for 14 patients treated by the thalidomide combined with chemotherapy.Statistic significance was present between them.Adverse effects were less and tolerated.Conclusion Treatment of small dose of thalidomide combined with COMP chemotherapy could significantly improve the effective rate with less adverse effects.
