Cytotoxicity and cellular imaging of quantum dots protected by polyelectrolyte
10.1016/j.jpha.2012.02.003
- Author:
Haiyan HU
;
Xingru DOU
;
Zonglin JIANG
;
Jianhua TANG
;
Lian XIE
;
Hongping XIE
- Publication Type:Journal Article
- Keywords:
CdTe quantum dots;
Poly-diallyldimethylammonium chloride;
Nanocomposites;
Cytotoxicity;
Cellular imaging
- From:
Journal of Pharmaceutical Analysis
2012;02(4):293-297
- CountryChina
- Language:Chinese
-
Abstract:
The nanocomposites of poly-diallyldimethylammonium chloride (PDADMAC) and CdTe quantum dots (QDs) (i.e.QDs-PDADMAC nanocomposites) have been prepared based on electrostatic interaction and their fluorescence stability in aqueous solution has been investigated. MTT method(3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide method) was used to study their cytotoxicity and A549 lung cancer cell as a model cell was also used to evaluate their cellular imaging.It was shown that the fluorescence stability of QDs-PDADMAC nanocomposites was much better than that of bare QDs both in aqueous solution and cell.Meanwhile,QDs-PDADMAC nanocomposites display very low cytotoxicity in the low concentrations and better staining ability compared with QDs.QDs-PDADMAC nanocomposites will have great advantage on the cell analysis detection and imaging.
