Improved nonmyeloablative allogeneic peripheral blood stem cell transplantation for severe aplastic anemia

VernacularTitle:改良非清髓造血干细胞移植治疗重型再生障碍性贫血
Author: Zhe YU ; Linfu GE ; Ning HUANG ; Ximin LIU ; Fang ZHOU ; Linna XIE
Publication Type:Journal Article
Keywords: Hemotopoietic stem celltransplantation; Transplantation conditioning; Anemia; Aplastic
From: Journal of Leukemia & Lymphoma 2009;18(8):476-477
CountryChina
Language:Chinese
Abstract: Objective To summarize the experience of improved nonmyeloablative hematopoietic stem cell transplantation(NSCT) in the treatment of severe aplastie anemia. Methods Seventeen patients with Severe Aplastic Anemia received NSCT after a nonmyeloablative conditioning.The patients were conditioned with decreased dosage of immunosuppressive agents of CTX and anti-lymphoid cell globulin or anti-thymus gland cell globulins;CsA and MMF were used to prevent the graft-versus-host disease (GVHD) after transplantation. Results 75 % of severe aplastic anemia in patients with type Ⅰ and 60 % of severe aplastic anemia in patients with type Ⅱ achieved rapid hematopoietic reconstitution, with good prognosis and implantation rate with fewer complieations and light symptoms were observed. Conclusion NSCT is an effective treatment of severe aplastic anemia.