Genetic prognostic markers for acute myeloid leukemia with normal cytogenetics

VernacularTitle:正常核型急性髓系白血病中具有预后意义的基因改变
Author: Fan WU
Publication Type:Journal Article
Keywords: Leukemia,myelocytic,acute; Mutation; Normal karyotype; Prognosis
From: Journal of Leukemia & Lymphoma 2011;20(7):436-439
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia (AML) is a heterogenous disorder disease, about 40 %-49 % of the adult AML and 25 % of children had normal karyotype AML, and usually categorized as an intermediaterisk group, but for acquired genetic change, such as mutations of FLT3, NPM1, CEBPα, MLL, and KIT as well as alterations in expression levels of BAALC, MN1, ERG, and EVI1, leading to significant heterogeneity for the prognosis of this group. In this report, prognostic genetic findings in normal karyotypical AML and discuss their clinical implications was reviewed.