Changes of Cardiotrophin-1 and Brain Natriuretic Peptide after Off-Pump Coronary Artery Bypass
10.3969/j.issn.0253-9896.2009.10.003
- VernacularTitle:非体外循环冠脉搭桥术后心肌营养素-1与脑钠尿肽变化
- Author:
Tongyun CHEN
;
Shuo REN
;
Qiang FU
;
Lianxiang ZHANG
;
Yulan ZHANG
;
Minxin WEI
- Publication Type:Journal Article
- Keywords:
coronary artery bypass;
off-pump;
myocardium;
natriuretic peptide;
brain;
cardiac surgical procedures
- From:
Tianjin Medical Journal
2009;37(10):823-825
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the changes of peripheral cardiotrophin-1 (CT-1) and brain natriuretic peptide (BNP) concentrations in patients undergoing off-pump coronary artery bypass grafting (OPCABC), and the clinical significance of peripheral CT-1 and BNP in cardiac surgery thereof. Methods:Fifty elective OPCABG patients were included in the study. The concentrations of CT-l and BNP were measured before surgery, and at 6 hours, 72 hours, 1 week and 10 months after the operation respectively. The clinical data of the heart function were also collected in patients . Results:(1 )The peripheral CT-1 levels were significantly higher at 10 months after OPCABC than those before operation. (2 )The concentration of peripheral BNP increased at 6 hours after operation. The peak level was found at 72 hours, and remained higher level until the 1 week after operation. The BNP concentration was returned to the normal level at 10 months after OPCABG. (3 )The baseline levels of CT-1 and BNP were both positively correlated with NYHA rank and the diameter of the left ventricular end-diastolic dimension (LVEED), but negatively correlated with left ventricular ejection fraction (LVEF). However, no correlations were found between CT-1 and BNP and NYHA rank, LVEF or LVEED at 10 months after OPCAB. Conclusion:The perioperative blood BNP levels were increased significantly by OPCABG, while perioperative level of CT-1 increased slowly compared with that of BNP. In cardiac surgery,perioperative concentrations of CT-1 and BNP may reflect the cardiac function in patients before OPCABG. The further studies are warranted to assess the prognosis.
