Quantitative analysis of contrast-enhanced ultrasonography on hepatocellular carcinoma: Correlation with tumor differentiated grades
10.3321/j.issn:1003-3289.2009.12.027
- VernacularTitle:肝细胞癌超声造影定量分析与肿瘤病理分级的相关性
- Author:
Peili FAN
;
Hong DING
;
Jiakai GUO
;
Xiyuan LIN
;
Yuan JI
;
Huichuan SUN
;
Wenping WANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
interventional;
Liver neoplasms;
Tumor grades
- From:
Chinese Journal of Medical Imaging Technology
2009;25(12):2243-2245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between hemodynamic parameters from quantitative analysis of contrast-enhanced ultrasonography (CEUS) on hepatocellular carcinoma (HCC) and pathological tumor differentiated grades. Methods Seventy-seven HCC lesions were examinated and off-line analyzed with dynamic images. Quantitative parameters such as slope of decrease to half of peak (SD), increased signal intensity (ISI), area under the curve (AUC) and blood flow coefficient (BF) were acquired, and the standardized values (sISI, sAUC and sBF) included the ratio of parameters from tumor to those from hepatic parenchyma. These quantitative parameters were correlated with tumor grades according to Edmonson criteria. Results There was significant difference (P＜0.05) of SD, AUC and BF, as well as standardized values (sISI, sAUC and sBF) between different grades of HCC. AUC, BF, sISI, sAUC and sBF were negative correlated with differentiated grades, respectively (P＜0.05). Well-differentiated HCC had significantly higher perfusion values than HCC of other grades (P＜0.05). Conclusion Quantitative analysis of CEUS can assess differentiation of HCC indirectly, and might reveal biological behavior of malignant tumors.
