Expression and significance of breast cancer suscepterbility gene 1 in leukemia
10.3760/cma.j.issn.1009-9921.2012.10.004
- VernacularTitle:BRCA1基因在白血病中的表达及其临床意义
- Author:
Chunxia MAO
;
Fengru LIN
;
Zhimin ZHANG
- Publication Type:Journal Article
- Keywords:
Breast cancer suscepterbility gene 1;
Leukemia;
Expression
- From:
Journal of Leukemia & Lymphoma
2012;21(10):589-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of breast cancer suscepterbility gene 1 (BRCA1) in leukemia.Methods Fluorescent quantitative reverse transcription-polymerase PCR was used to investigate the expression of BRCA1 in 18 patients with ALL-L2 (13 denovo ALL patients,5 relapsed ALL patients),20 patients with CML-CP and 15 normal controls.Results The mRNA expression of BRCA1 in denovo patients with ALL was lower than that in normal control,with statistical significance (P ＜ 0.05).The mRNA level of BRCA1 in ALL patients in CR was higher compared with before to cure, with statistical significance (P ＜ 0.05),but lower than that in normal control,without statistical significance(P ＞ 0.05).The mRNA expression of BRCA1 in patients with relapsed ALL was lower than that in normal control with statistical significance (P ＜ 0.05), and lower than that in denovo patients with ALL, without statistical significance (P ＞ 0.05).The mRNA level of BRCA1 showed no difference in CML-CP patients compared with normal control (P ＞ 0.05). Conclusion The different expression of BRCA1 in leukemia indicates that he has closely relationship with the prognosis of leukemia and guides the clinical diagnosis and treatment.
