Malignant pleural effusion of multiple myeloma
10.3760/cma.j.issn.1009-9921.2010.07.008
- VernacularTitle:多发性骨髓瘤合并胸腔积液的临床观察
- Author:
Jiajia ZHANG
;
Yuping ZHONG
;
Xin LI
;
Ying HU
;
Na AN
;
Xiaohui LIU
;
Shilun CHEN
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Pleural effusion;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2010;19(7):407-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics, prognosis and treatment of pleural effusion of multiple myeloma. Methods From Jun 2005 to March 2010, of 162 patients with multiple myeloma treated in our department were complicated with pleural effusion, whose the proportion male to female was 8:7 and the median age was 56.8 (37-68) years. The diagnosis of malignant pleural effusion was dependent on physical examination, chest X ray, pleural aspiration and pleural fluid cytology. According to internatinal system stages and Durie-Salmon stages, the patients were staged. Results The results of pleural fluid cytology showed that the myeloma cells were positive in 13 patients and was negative in the other 2 patients. All patients received the chemotherapy regimen including bortezomib, large dose of glucocorticoids and cisplatin, cyclophosphamide, etoposide or prednisone (DECP). Although pleural effusion was controlled in some degrees, but were quickly relapsed. Eleven patients died, 2 of steady disease and 2 follow-up. Conclusion Multiple myeloma with myelomatous pleural effusion was very poor in the prognosis. Myelomatous pleural effusion was taken as a late manifestation in multiple myeloma or prediction of the aggressive behavior of the disease.
