Correlation between 18F-FDG PET/CT SUV and immunohistochemical expression of tumor associated molecular markers in non-small-cell lung cancer
10.3321/j.issn:1003-3289.2009.07.045
- VernacularTitle:非小细胞肺癌18F-FDG PET/CT显像标准化摄取值与肿瘤分子标志物表达的相关性
- Author:
Yu DUAN
;
Lijuan YU
;
Bo HAN
;
Chengye JIA
;
Xin WANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Fluorodeoxyglucose F18;
Standard uptake value;
Tumoral molecular-biological index;
Tomography,emission-computed
- From:
Chinese Journal of Medical Imaging Technology
2009;25(7):1279-1282
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between 18F-FDG SUV and immunohistochemical index including GLUT1, Ki-67, MVD, survivin and cyclinA in non-snall-cell lung cancer. Methods Thirty-three patients with NSCLC underwent preoperative PET/CT examination and surgical operation. All patients were divided into two groups according to the size of tumor (cutoff=3 cm), metastasis of mediastinal or hilar lymph nodes or not, and histological types of the cancer, respectively. The expression of GLUT1, Ki-67, MVD, survivin and cyclinA were estimated with SP immunohistochemical technique, and were analyzed statistically to reveal the correlation to FDG SUV. Results The rate of positive expression of GLUT1, Ki-67 and CD34 were 66.67%, 72.73% and 100%, respectively. The mean value of CD34 in all 33 patients was 12.6±2.9 (12-56). The rate of positive expression of survivin was 84.85%, and the corresponding data of cyclinA was 27.27%. Conclusion There is linear correlation between FDG PET SUV and GLUT1, but not between FDG PET SUV and Ki-67, MVD, survivin and cyclinA. The expressions of GLUT1, Ki-67, MVD, survivin and cyclinA are not related with the size of tumor, nor metastasis of lymph nodes. The expression of GLUT1 and Ki-67 is related with histological types of the cancer, but not with MVD, survivin and cyclinA.
