Correlation of vascular endothelial growth factor with metastasis of non-Hodgkin lymphoma
10.3760/cma.j.issn.1009-9921.2008.05.019
- VernacularTitle:血管内皮生长因子与非霍奇金淋巴瘤浸润的相关性研究
- Author:
Xi LI
;
Qiaohua ZHANG
;
Shuling HOU
- Publication Type:Journal Article
- Keywords:
Lymphoma,non-Hodgkin;
Vascular endothelial growth factors;
L-lactate dehydrogenase
- From:
Journal of Leukemia & Lymphoma
2008;17(5):369-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of vascular endothelial growth factor(VEGF)with the invasion and metastasis of non-Hodgkin lymphoma.Methods The levels of serum VEGF was measured by enzyme linked-immunoadsorbent assay(ELISA).Comparing the parameters between NHL group and the control group.Compared the parameters with different groups divided by clinical stage,the effect of the treatment,the level of plasma LDH and effect of treatment.Analyzed the correlation of the levels of serum VEGF and plasma LDH in patients of NHL.Results The levels of serum VEGF are remarkablely higher in patients than that in the control group(P＜0.05).The levels of serum VEGF in the group of Ⅲ,Ⅳ clinical stage are higher than that in the group of Ⅰ,Ⅱ clinical stage,but no significant difference(P＞0.05)were observed.The level of serum VEGF is higher in the group of none CR than the group of CR(P＜0.05).The level of serum VEGF is higher in the group of non-normal level of plasma LDH than group of normal LDH level(P＜0.05).The levels of VEGF and LDH are significantly correlated each other(P＜0.01).Conclusion The angiogenesis are important for tumor metastasis in patients of NHL.The serum VEGF can be used as prognosis parameters in patients with NHL.
