Model establishment of DBA/2 mouse minimal residual leukemia

VernacularTitle:DBA/2小鼠微小残留白血病模型的构建
Author: Xueyu CAI ; Caiping CHEN
Publication Type:Journal Article
Keywords: Leukemia; Mice; Model; animal
From: Journal of Leukemia & Lymphoma 2009;18(8):455-457
CountryChina
Language:Chinese
Abstract: Objective To establish a cell line and a convenient and well-duplicated minimal residual leukemia (MRL) model. Methods We chose the international standard domestic inbred DBA/2 mouse to inoculate the different numbers of L1210 leukemic cells to investigate the relationship between inoculating cell number and mouse survival time. On the third day after 1×106 leukemic cells per mouse were inoculated, different doses of CTX were used for the chemotherapy. Results The inoculating number of L1210 leukemic cells increased while the mouse survival time decreased;The survival time increased following the increase of the doses of the CTX;The survival time of the inoculated mouse treated with CTX at 125 mg/kg was equal to that of the mouse inoculated with 500 L1210 leukemic cells without treatment. Conclusion The observation results are that the dose of 125 mg/kg for creating the model of MRL mouse.