Etiology and clinical features of hepatic dysfunction in patients after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2012.08.009
- VernacularTitle:异基因造血干细胞移植后患者肝损害病因与临床特征分析
- Author:
Qian WANG
;
Yuewen FU
;
Yanli ZHANG
;
Baijun FANG
;
Jian ZHOU
;
Xudong WEI
;
Yongping SONG
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Hepatic dysfunction;
Graft versus host disease;
Hepatic veno-occlusive disease;
Drug
- From:
Journal of Leukemia & Lymphoma
2012;21(8):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize and evaluate the incidence,etiology,diagnostic and therapeutic method of hepatic dysfunction after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods 83 blood disease patients who undergoing allo-HSCT from 2006 to 2010 in the affiliated cancer hospital of Zhengzhou university.Among those who suffered from Ⅱ-Ⅳ grade hepatic dysfunction,the incidence,the ratio of different causes,clinical feature and diagnostic method were evaluated.The difference of causes of hepatic dysfunction in different period,the therapeutic method and curative effect were also analysed.Results Among 83 patients undergoing allo-HSCT,45 patients suffered from Ⅱ-Ⅳ grade hepatic dysfunction,the ratio was 54.2 ％.For etiology,7 were preconditioning,9 were cyclosporine (CsA),2 were hepatic venoocclusive disease (HVOD),24 were hepatic graft versus host disease (GVHD),2 was hepatic B virus (HBV)reactivation,1 was mutiple organ failure.20 cases (44.4 ％) occurred in one month after allo-HSCT with the main etiology of drug hepatotoxicity.13 cases (28.9 ％) occurred from one month to 100 days after allo-HSCT,while 12 cases (26.7 ％) occurred from 101 days to one year with the main etiology of both hepatic GVHD.27 cases were cured and 10 were improved after treatment.2 cases were not cured and 6 cases died from relapse of the primary disease,or else from the complication of allo-HSCT.Conclusion Hepatic dysfunction is an common complication after allo-HSCT,drug hepatotoxicity and hepatic GVHD are the major causes.The relativity between hepatic dysfunction and period after allo-HSCT is a important reference for diagnosis.It will produce desired result to choose proper therapeutic method based on etiology.
