Study on serum erythropoietin levels in patients of hematologic malignancies with aneamia and application of recombinant human erythropoietin

VernacularTitle:血液肿瘤贫血患者内源性促红细胞生成素水平与基因重组人促红细胞生成素应用研究
Author: Lingsong CHEN ; Qiurong ZHANG ; Xingguo CHEN ; Wenwei SONG ; Guihua ZHANG ; Jinge XU ; Lanyun LI ; Yongsheng LI ; Yihong HUANG
Publication Type:Journal Article
Keywords: Anemia; Hematopogic neoplasms; Erythropoietin
From: Journal of Leukemia & Lymphoma 2009;18(11):681-683
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of recombinant human erythropoietin (rhEPO) in patients of hematologic malignancies with aneamia and its relationship of serum erythropoietin levels. Methods Serum EPO (sEPO) level in 80 patients with hematologic malignancies were detected by chemolumimiscence,and treated by recombinant human erythropoietin for patients with Hb<100 g/L. Results The effect on aneamia in tumor patients with remission were significantly higher than that with no-remission. The patients with lower level of sEPO had better respose to treatment by rhEPO than patients with higher level. Conclusion Higher level of sEPO in patients with no-remission hematopoietic tumor, with condition of marrow erythropoiesis aplasia, the effect of rhEPO was poor;, but sEPO level in patients with remission hematopoietic tumor were nearly normal with recovery of marrow erythropoiesis aplasia was effective by use of rhEPO.