Advance on mediastinal gray zone lymphoma
10.3760/cma.j.issn.1009-9921.2011.03.018
- VernacularTitle:纵隔灰区淋巴瘤的研究进展
- Author:
Ni FAN
- Publication Type:Journal Article
- Keywords:
Gray zone lymphoma;
Lymphoma,non-Hodgkin;
Diagnosis,differential
- From:
Journal of Leukemia & Lymphoma
2011;20(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
As a distinct clinicopathological entity, mediastinal gray zone lymphoma cannot be classified by using differential diagnostic criteria. The cases represent a spectrum of tumors having characteristics of both primary mediastinal large B-cell lymphoma (PMBL) and classic Hodgkin lymphoma (cHL). In the 2008 WHO Classification, a novel category designated B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu) has been created to include these neoplasms. The main features of BCLu are clearly different from those of conventional mediastinal large B-cell lymphomas. Diagnosis of BCLu requires a multiparameter approach incorporating morphological, immunophenotypic, immunohistochemical and other features. These lymphomas generally have a more aggressive clinical course and poorer outcome. There is no consensus on the optimum treatment, while the recommended therapies for aggressive B-cell lymphomas might be effective options.
