Treatment of refractory and relapsed acute leukemia in 25 adult patients with MAAE regimen

VernacularTitle:MAAE方案治疗复发难治急性白血病25例
Author: Mingjun HU ; Yu LIU ; Zhenghua ZHANG ; Yunjing XIA ; Chucheng WAN
Publication Type:Journal Article
Keywords: Leukemia; Recurrence; Antineoplastic combined chemotherapy protocols
From: Journal of Leukemia & Lymphoma 2008;17(2):129-130
CountryChina
Language:Chinese
Abstract: Objective To analyze on the efficacy and toxicity of MAAE (MIT ,Ara-C,AMSA,VP16)regimens on treating refractory and relapsed acute leukemia in adult patients. Methods MAAE (MIT, Ara-C,AMSA, VP16) regimen, which consisted of MIT 10mg/d (d1～3), intravenousdrop, Ara-C 200mg/d (d1～7),intravenousdrop, AMSA 75 mg/d (d1～3), intravenousdrop VP16 100 mg/d(d1～4), intravenousdrop were used to treat 25 cases of adults with refractory and relapsed acute leukemia (AL). G-CSF 5 μg/kg were used every day when WBC＜0.5×109/L. Results In the 25 cases with refractory and relapsed acute leukemia, 14 cases (56 %) reached complete remission, 5 patients(20 %) reached partial remission, the total effective rate was 76 %. Conclusion MAAE regimen was a very effective alternative treatment for CR induction in adult patients with refractory and relapsed AL and low toxicity.