Immunophonotype of acute myeloid leukemia and mixed leukemia detected by flow cytometry

VernacularTitle:急性髓系及混合型白血病流式细胞术免疫分型检测结果
Author: Gendong YAO ; Hongqi HUO ; Peng LI ; Aimin LIU
Publication Type:Journal Article
Keywords: Leukemia,myeloid,acute; Leukemia,mixed-cell; Flow cytometry; Immunophenotyping
From: Journal of Leukemia & Lymphoma 2010;19(12):746-747
CountryChina
Language:Chinese
Abstract: Objective To detect by flow cytometry (FCM) acute myeloid leukemia. Methods Fourcolor staining was used for analysis of immunphonotypes of 52 cases with acute myeloid leukemia and 7 cases of mixed leukaemia. Results 52 cases with series of patients with AML expression, with the main expression CD13 (94.2 %), CD117 (90.4 %), cMPO (90.4 %) CD33 (86.5 %), CD34 (57.7 %), HLA-DR (53.8 %). In 7 cases of mixed cell leukemia 3 cases of myeloid/B (M/B), are expressing CD13, CD34, CD117, CD10, CD19, cMPO, cCD79a.Myeloid/T (M/T) 2 cases with expression of CD13, CD117, CD33, CD34, CD5,CD7, cMPO; B department/T (B/T) 2cases, with expression of CD5, CD7, CD10, CD19, CD20, CD34. And with the morphological and organizations with high accuracy of chemical diagnosis. Conclusion FCM can improve the diagnose rate for AML and mixed leukemia. And has played an important clinical significance.