Advance in research of B-cell lymphoma stem cells
10.3760/cma.j.issn.1009-9921.2011.10.021
- VernacularTitle:B细胞淋巴瘤干细胞的研究进展
- Author:
Jing DING
- Publication Type:Journal Article
- Keywords:
B-lymphocytes;
Lymphoma,non-Hodgkin;
Stem cells
- From:
Journal of Leukemia & Lymphoma
2011;20(10):628-630
- CountryChina
- Language:Chinese
-
Abstract:
Origin of lymphoma stem cells is very complicated,it is proposed that committed lymphoid progenitor/precursor cells(CLP)with V-D-J recombination are stem cells of follicular lymphoma(FL)and mantle cell lymphoma (MCL).Conversely,B lymphocytes within the germinal center as the diffuse large B-cell lymphoma (DLBCL)and sporadic Burkitt lymphoma (BL)stem cells.An alternative model supports an epigenetic modification of genes as the first occurring hit,which leads to retaining stem-cell features in hematopoietic cells, followed by secondary chromosomal translocations that eventually transformed into lymphoma.Isolation and characterization of the different B-cell non-Hodgkin lymphomas will provide critical insights into the disease pathogenesis and will represent a step towards the development of more effective therapies.
