Correlati on between JAK2V617F mutation and clinical characteristics in patients with myeloproliferative neoplasm
10.3760/cma.j.issn.1009-9921.2012.07.008
- VernacularTitle:骨髓增殖性肿瘤JAK2V617F基因突变与疾病临床特征的相关性分析
- Author:
Wenwen LI
;
Xiaoyan ZHANG
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
Myeloproliferative neoplasm;
JAK2V617F mutation;
Leukocyte;
Hemoglobin;
Thrombosis;
Vascular disease
- From:
Journal of Leukemia & Lymphoma
2012;21(7):412-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between JAK2V617F mutation and clinical characteristics in patients with myeloproliferative neoplasm(MPN) in Xinjiang area.Methods The correlation between JAK2V617F mutation and clinical characteristics about gender,age,nationality,leukocyte counts,platelet counts,hemoglobin and LDH levels,complications of thrombosis,bleeding and vascular disease in 134patients with MPN were analyzed. Results 73.1％ (98/134) JAK2V617F mutation was found in patients (51with PV,66 with ET, 17 with IMF). Compared with negtive mutation, the rata of ≥60 years was significantly higher in positive group [78.6 ％(77/98)vs25.0 ％(9/36)(χ2=32.867,P＜0.001)]. Patients harboring JAK2V617F mutation have higher leukocyte counts[(15.9±8.2)×109/L vs (9.6±5.3)×109 L,t=4.296,P＜0.001],hemoglobin levels [(156.4 ±44.9)g/L vs (133.8 ±44.1)g/L,t=2.590,P =0.011],incidence of thrombosis [73.5 ％(72/98)vs22.2 ％(8/36),χ2=28.740,P＜0.001)] and vascular diseas [81.6 ％(80/98)vs25.0 ％(9/36),χ2=37.859,P＜0.001)]. There was no significant difference in gender, nationality, platelet counts, LDH levels and bleeding complications between JAK2V617F positive and negative patients. Conclusion There is a correlation between JAK2V617F mutation in MPN and age,leukocyte counts,hemoglobin levels,thrombosis and vascular disease complications.
