Comparison of real-time and intermittent triggered myocardial contrast echocardiography in evaluation of mini-swine myocardial no-reflow phenomenon
- VernacularTitle:实时和间歇触发心肌声学造影评价小型猪心肌无复流现象对比观察
- Author:
Aili LI
;
Yuannan KE
;
Xianlun LI
;
Peng YANG
;
Wenhua PENG
;
Jing LI
;
Changan YU
- Publication Type:Journal Article
- Keywords:
Ultrasonography,interventional;
Echocardiography,three-dimensional;
Animal experimentation
- From:Chinese Journal of Medical Imaging Technology
2010;26(1):25-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of real-time myocardial contrast echocardiography (RTMCE) and intermittent triggered myocardial contrast echocardiography (ITMCE) in the detection of myocardial no-reflow phenomenon after reperfusion in acute myocardial infarction on mini-swine models. Methods Thirty close-chest mini-swines were used to create acute myocardial infarction and reperfusion model through interventional method. RTMCE and ITMCE were performed at baseline, 2 h after occlusion of left anterior descending coronary artery and 3 h after reperfusion. The myocardial perfusion defects after occlusion was measured as risk area (RA) and that after reperfusion was measured as no-reflow area (NRA). NRA/RA was calculated and compared with pathological findings. Results The whole study protocol was successfully performed in 27 mini-swines. NRA/RA obtained from RTMCE, ITMCE and pathological staining was (47.94±21.29)%, (38.20±21.04)% and (30.07±14.62)% , respectively. NRA/RA had no significant difference by ITMCE and pathological staining (P=0.124), RTMCE and ITMCE (P=0.071). The correlation coefficient of RTMCE and staining was 0.700 (P<0.001), ITMCE and staining was 0.765 (P<0.001), RTMCE and ITMCE was 0.897 (P<0.001). The sensitivity, specificity and accuracy in the detection of myocardial no-reflow was 100%, 58.33% and 79.17% for RTMCE, 91.67%, 73.33% and 81.48% for ITMCE. Conclusion Both RTMCE and ITMCE could be used as noninvasive methods to reveal the myocardial perfusion and quantitatively detect myocardial no-reflow after reperfusion therapy.
