Expression of Tumor Metastasis Associated Gene Ezrin in Nasopharyngeal Carcinoma
10.3969/j.issn.0253-9896.2009.07.006
- VernacularTitle:鼻咽癌中肿瘤转移相关基因Ezrin的表达及临床意义
- Author:
Ping LI
;
Zhuxin WEI
;
Wei LU
;
Hua WANG
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
nasopharyngeal eoplasms;
carcinoma;
neoplasm metastasis;
connexins gene expression;
immanohistochemistry
- From:
Tianjin Medical Journal
2009;37(7):544-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression and clinical significance of Ezrin, a tumor metastasis related gene, in tissues of nasopharyngeal carcinoma (NPC). Methods: The expression of Ezrin was detected with two-step immunohistochemistry technique in tissues of 38 NPC patients and 20 nasopharyngitis patients. All of the Ezrin expression and clinical data (gender, age, clinical stage, recurrence, and ]ymphonode metastasis) were compared and analyzed between two groups. Resuits: The Ezrin expressions were significantly different between NPC tissue (and peri-NPC tissue) and naeopharyngitis tissue (P＜0.05). No significant difference was found in the Ezrin expressions between the NPC tissue and the peri-NPC tissue (P＞0.05). It was found by Spearman analysis method that the Ezrin expression increased with patients' age (P＜0.05), but no significam relationship with gender, clinical stage, recurrence, and lymphonode metastasis (P＞0.05). The Ezrin expression influenced the survival time of NPC patients significantly (P＜0.01). Conclusion: The Ezrin expression can be an useful prognostic factor for NPC patients.
