Establishment and pathological observation of rabbit remnant carcinoma models after RFA therapy
10.3321/j.issn:1003-3289.2009.10.007
- VernacularTitle:射频消融后残余肿瘤模型的制作及病理观察
- Author:
Dongfeng HE
;
Ke XU
;
Baoguo JIANG
;
Yue WANG
;
Haibo SHAO
;
Zhigang CAO
;
Xu DAI
;
Min GUO
;
Huijie JIANG
;
Ruibao LIU
- Publication Type:Journal Article
- Keywords:
Catheter ablation;
Models;
animal;
Remnant carcinoma
- From:
Chinese Journal of Medical Imaging Technology
2009;25(10):1753-1756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish rabbit model of remnant carcinoma after RFA therapy, and to observe pathomorphological changes of remnant carcinoma in different time. Methods Forty-eight New Zealand white rabbits underwent ultrasound-guided percutaneous inoculation with VX2 carcinoma, then RFA therapy was performed to made models of remnant carcinoma. These models were averagely divided into 6 groups randomly (each n=8). Rabbits in each group was killed and pathologically observed before RFA and 1 d, 3 d, 1 week, 2 and 3 weeks after operation, respectively. Results The expression of MVD,VEGF and PCNA in remnant VX2 carcinomas tissues decreased significantly, but increased 2-3 weeks after RFA. The remnant VX2 carcinomas tissues were in inhibitory state 2 weeks after RFA. Conclusion The growth of remnant carcinoma could be inhibited in short term after RFA. Further therapy is necessary.
