The expressions of HSP70 and alphaB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
- Author:
Mustafa Yavuz GULBAHAR
1
;
Yonca Betil KABAK
;
Mehmet Onder KARAYIGIT
;
Murat YARIM
;
Tolga GUVENC
;
Unal PARLAK
Author Information
- Publication Type:Original Article
- Keywords: apoptosis; foot-and-mouth disease virus type O; heat shock proteins; lamb; myocarditis
- MeSH: Animals; Apoptosis Regulatory Proteins/metabolism; Foot-and-Mouth Disease/*complications/*virology; Foot-and-Mouth Disease Virus/*classification; Gene Expression; HSP70 Heat-Shock Proteins/*metabolism; Myocarditis/complications/pathology/*veterinary/virology; Myocardium/pathology; Sheep; Sheep Diseases/*virology; Turkey; alpha-Crystallin B Chain/*metabolism
- From:Journal of Veterinary Science 2011;12(1):65-73
- CountryRepublic of Korea
- Language:English
- Abstract: This study describes the expression of heat shock protein70 (HSP70) and alpha-basic-crystallin (alpha-BC) and their association with apoptosis and some related adaptor proteins in the pathogenesis of foot-and-mouth disease virus (FMDV)-induced myocarditis in lambs. HSP70 was generally overexpressed in the myocardial tissues and inflammatory cells of FMDV-induced myocarditis with differential accumulation and localization in same hearts when compared to non-foot-and-mouth disease control hearts. alpha-BC immunolabeling showed coarse aggregations in the Z line of the cardiomyocytes in FMDV-infected hearts in contrast to control hearts. Overall, the results of this study show that the anti-apoptotic proteins, HSP70 and alpha-BC, were overexpressed with increased apoptosis in FMDV-infected heart tissues. Both proteins failed to protect the cardiomyocytes from apoptosis as defense mechanisms to the FMDV during the infection, suggesting that the virus is able to increase apoptosis via both downregulation and/or upregulation of these anti-apoptotic proteins.
