Comparative analysis of the curative effect on CML in chronic phase by different courses of HA combination regimen
10.3760/cma.j.issn.1009-9921.2009.06.011
- VernacularTitle:五天与七天HA方案治疗慢性粒细胞白血病慢性期的临床分析
- Author:
Aihong SUN
;
Bin HE
;
Mei SUN
;
Zhongqiang WANG
;
Yu ZHANG
;
Jian GU
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,chronic-phase;
HA combined chemotherapy protocols
- From:
Journal of Leukemia & Lymphoma
2009;18(6):353-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and adverse effects of 5 days' and 7 days' course of combination chemotherapy regimen HA in the treatment of chronic phase of chronic myelogenous leukemia (CML-CP). Methods 18 cases of CML-CP had received 5 days' course of combination chemotherapy regimen HA including homoharringtonine 4 mg/d and cytarabine 200 mg/d for 5 days. At the same time,another 18 patients diagnosed as CML-CP who were given 7 days' course of HA regimen including homoharringtonine 4 mg/d and cytarabine 200 mg/d for 7 days were compared on the efficacy including peripheral white blood cells, spleen size and cytogenetic responses and adverse effects. Results The complete remission(CR) rate was 50.0 % and 61.1 % in 5 days' and 7 days' treated groups, respectively (P >0.05). The incidence of severe bone marrow suppression in 7 days' group(16.7 %) was higher than that in 5 days' group(0)(P <0.05). Conclusion The 5 days' course of combination chemotherapy HA regimen is same as 7 days' course of HA regimen about their curative effects in CML-CP. But the incidence of severe bone marrow suppression in 7 days' group(16.7 %) was higher than that in 5 days' group (0).
