Polymorphisms of DNA repair genes XRCC1 and susceptibility to non-Hodgkin lymphoma

Lijuan REN; Qiaohua ZHANG; Jingyi SHI; Qunling ZHANG; Xiaoxing JIANG; Shuling HOU; Yunpeng HUANG; Weili ZHAO

白话标题:DNA修复基因XRCC1单核苷酸多态性与非霍奇金淋巴瘤遗传易感性的关系
作者: Lijuan REN ; Qiaohua ZHANG ; Jingyi SHI ; Qunling ZHANG ; Xiaoxing JIANG ; Shuling HOU ; Yunpeng HUANG ; Weili ZHAO
出版类型:Journal Article
关键字: Lymphoma,non-Hodgkin; Polymorphism,single nucleotide; Susceptibility; XRCCl
来源: Journal of Leukemia & Lymphoma 2009;18(4):197-200
国家China
语言:Chinese
摘要: Objective To investigate the correlation between XRCC1 R280H,XRCCl TSS+29C/T genetic polymorphisma and susceptibility to non-Hodgkin lymphoma (NHL). Methods The MassARRAY method was applied to detect the DNA repair gene XRCC1 genetic polymorphisms in 73 cases of NHL and 540 cases of normal healthy controls. Chi-square test was performed to calculate the adjusted odds ratios (OR) and 95% confidence intervals (CI). Results For XRCCl R280H genotypes, there was a significant difference between frequencies of the G and A among patients and controls (P=0.001). However, XRCCl TSS+29C/T genotypes had no statistical difference as for the T and C frequencies between patients and controls (P = 0.383). The frequency of XRCCI R280H with at least one A genotype was lower in the NHL cases than in controls, indicating a decreased risk for NHL development (OR=0.309, 95 % CI =0.168-0.567), comparing with GG genotype. In XRCC1 TSS+29C/T genotypes, the frequeney of TC and CC genotype was higher in NHL cases than in controls and associated with an increased risk of NHL development (P=0.472, OR =1.262, 95 % CI =0.669-2.379). Conclusion DNA repair XRCCl gene possesses significant correlation with NHL.