Correlation of P-gp,bcl-2,STAT3 and the resistance of lymphoma cells to chemotherapeutic agents
10.3760/cma.j.issn.1009-9921.2009.012.008
- VernacularTitle:淋巴瘤细胞膜P糖蛋白、信号转导与转录激活因子3及bcl-2表达水平与化疗耐药的相关性
- Author:
Shulin HOU
;
Lijuan QIAO
;
Qiaohua ZHANG
;
Xi LI
;
Zhiqiang ZHAO
;
Yunpeng HUANG
- Publication Type:Journal Article
- Keywords:
Lymphoma;
P-glyeoprotein;
Proto-oneogene proteins C-bcl-2;
Activating transcription factor 3;
Combination;
Drug resistance;
neoplasms
- From:
Journal of Leukemia & Lymphoma
2009;18(12):732-734
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of P-gP,bel-2,STAT3,IL-6,IL-10 and the resistance lymphoma cells to chemotherapeutic agents.Methods There were 28 patients,among them were divided into three groups:refractory lymphoma,lymphoma which is sensitive to agents and lymphodenitis.P-glycoprotein(P-gp)on lymphoma cell membrane,STAT3,bcl-2,IL-6 and IL-10 level into lymphonla cell were detected using FCM,and the correlation between them and chemotherapy efficacy were analysed. Results In refractory lymphoma patients,P-gp and hcl-2 are significant higher than that of the group which is sensitive to agents(P:0.01,P=0.039),but STAT3,IL-6 and IL-10 were not significant different between these two groups(P>o.05).P-gp is significant higher in lymphoma than in lymphodenitis(P=0.01).STAT3 in lymphoma is significant lower than that of in lymphodenitis (P=0.04).The level bcl-2,IL-6 and IL-10 between lymphoma and lymphodenitis are not significant different(P>0.05).Conclusion The expression level of bel-2 and p-gP is correlated to resistance to the chemotherapeutic agents in lymphoma cells.STAT3 play a role in lymphoma cell signal transduction,but it is not certain in lymphoma cell muhidrug resistance.
