Expression and significance of COX-2, bd-2, Caspase-3 in diffuse large B-cell lymphoma

VernacularTitle:COX-2、bcl-2、Caspase-3在弥漫大B细胞淋巴瘤中表达的意义
Author: Jie LI ; Hongling HAO ; Liying XUE ; Chao WANG ; Suyun WANG ; Ruicang WANG
Publication Type:Journal Article
Keywords: Lymphoma,large-cell,diffuse; Cyelooxygenase 2; Genes,bel-2; Caspase-3
From: Journal of Leukemia & Lymphoma 2009;18(4):223-225
CountryChina
Language:Chinese
Abstract: Objective To explore the expressions and correlation of COX-2, bcl-2 and Caspase-3 in diffuse large B-cell lymphoma(DLBCL). Methods The expression of COX-2, bcl-2 and Caspase-3 was studied in 29 cases of DLBCL and 10 cases of reactivited lymphoid tissue with immunohistochemistry of PowerVisionTM. Results The expression of COX-2 and bcl-2 are seperately 68.9 % and 72.4 %. The expression of COX-2 had correlation with Ann Arbor stage. The expression of COX-2 was positively correlated with that of bcl-2, the expression of bcl-2 was negatively correlated with that of Caspase-3, the expression of COX-2 was negatively correlated with that of Caspase-3. Conclusion COX-2, bcl-2 and Caspase-3 may be involved in the carcinogenesis of DLBCL, and their expression may be helpful in estimating the histology grade and prognosis of DLBCL.