Continuous low-dose cyclophosphamide and prednisone treatment of 84 cases relapsed and refractory multiple myeloma
10.3760/cma.j.issn.1009-9921.2012.05.010
- VernacularTitle:持续低剂量环磷酰胺联合泼尼松治疗复发、难治性多发性骨髓瘤84例
- Author:
Lieping GUO
;
Fan ZHOU
;
Wei WEI
;
Yizi ZHANG
;
Haotian SHI
;
Chenhui LIN
;
Lu LI
;
Nan JIANG
;
Jian HOU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Cyclophosphamide;
Prednisone;
Recurrnce;
Refractory dieases
- From:
Journal of Leukemia & Lymphoma
2012;21(5):290-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy andtolerability of continuous low-dose cyclophosphamide and prednisone treatment of relapsed and refractory multiple myeloma. Methods84 relapsed and refractory multiple myeloma patients were enrolled, including 46 males and 38 females, the assess patients of 81 cases with average age of 69.7 (45-91)years. They were treated continuous with oral cyclophosphamide (50 mg/d) and prednisone (15 mg/d) and monthly follow-up.ResultsAverage follow-up time were 23.5(1-71)months.The assessed patients were 81 cases,with 52 cases (64.2 ％) responded.There were 2 cases(2.5 ％)CR,21 cases(25.9 ％) of PR,29 cases(35.8 ％)MR,19 cases(23.5 ％)NC and 10 cases (12.3 ％)PD.The median time to response was 2 months.In the patients who responded to the treatment,the median progression-free survival(PFS)and overall survival (OS) were 18(95 ％CI 12.8-23.2),29(95 ％CI 24.1-33.9)months.In the non-responding patients,the PFS and OS were 4(95 ％ CI 2.2-5.8) and 6(95 ％ CI 4.9-7.1)months.Two groups were statistically significant(P＜0.05).The most common toxicities included fatigue,nausea, neutropenia, hyperglycemia and lung infection. No patient withdrew from the study because of toxicity. Conclusions Continuous low-dose cyclophosphamide combined prednisone is a treatment options for relapsed and refractory MM patients.
