Progress of renal damage from multiple myeloma
10.3760/cma.j.issn.1009-9921.2011.11.021
- VernacularTitle:多发性骨髓瘤肾功能损伤的研究进展
- Author:
Chuanying GENG
;
Wenming CHEN
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Kidney damage;
Therapy
- From:
Journal of Leukemia & Lymphoma
2011;20(11):701-703
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma is a malignancy of plasma cells and renal function impairment is one of common complications of multiple myeloma.Light-chain deposition in renal tubules which induces renal tubular disease is the major pathogenesis of renal impairment.The renal function impairment should be estimated based on glomerular filtration rate in multiple myeloma patients. Bortezomib with high-dose dexamethasone is effective to myeloma patients with renal impairment and improves renal function.Treatment experience of thalidomide is limited,but it can be used at the standard dosage to patients with renal failure.Lenalidomide is effective and can reverse renal impairment of several myeloma patients when this agent is used at reduced doses according to renal function.
