The role of mesenchymal stem cells in supporting haemopoiesis and differentiation
10.3760/cma.j.issn.1009-9921.2010.12.020
- VernacularTitle:骨髓间充质干细胞支持造血细胞生成和分化机制的研究进展
- Author:
Luxi SONG
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Hematopoiesis;
Cell adhesion molecules;
Signal transduction;
Niche
- From:
Journal of Leukemia & Lymphoma
2010;19(12):761-765
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells(MSC) have the ability to self-renew and differentiate into tissues of mesodermal origin (osteocytes, adipocytes, chondrocytes), and the cellular constituents of the microenvironment, largely derive from a common progenitor of mesenchymal origin. MSC themselves and their large numbers of progeny form three kinds of niches(osteoblastic niche, stromal niche and adipocyte niche)which have a fully competent microenvironment to provide appropriate signals via production of soluble factors and cell contact interactions of adhesion molecules, by which they play the role in supporting haemopoiesis and differentiation. Many of the discoveries described herein may contribute to future clinical treatments for hematopoietic, including cancer.