Study of the expression of Ki-67,p53,bcl-2 related with prognosis of patients with malignant lymphoma after the autologous hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2009.03.006
- VernacularTitle:Ki-67、p53、bcl-2的表达与恶性淋巴瘤自体造血干细胞移植预后的相关性
- Author:
Xianming LIU
;
Huaqing WANG
;
Huilai ZHANG
;
Lanfang LI
;
Zhengzi QIAN
;
Xinghai LIU
;
Yun HOU
;
Xishan HAO
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Hematopoietic stem cell transplantation;
Prognosis;
Immunohistochemistry
- From:
Journal of Leukemia & Lymphoma
2009;18(3):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of bcl-2, p53, Ki-67 in malignant lymphoma (ML)and the relationship between the expression of bcl-2, Ki-67, p53 and prognosis for the patients who were given autologous hematopoietic stem cell transplantation (AHSCT). Methods The expression of bcl-2,Ki-67, p53 were measured by immunohistochemistry (IHC) on paraffin-embedded slices in 33 cases of ML who received AHSCT. Survival analysis was done by the Kaplan-Meier method and Log-Rank test.Multivariate analysis was carried out using COX proportional hazard model. Results For patients with ML who received AHSCT, the 3-year disease free survival (DFS) of bcl-2(+) group was 35.71%, while that bcl-2(-) group was 88.89 %. There was significant difference of DFS between the two groups. Meanwhile, for these patients, the 3-year DFS of Ki-67(+) and Ki-67(-) were 43.75 % and 85.71%, respectively (P ＜0.05).Multivariate analysis showed that the expression of bcl-2 and Ki-67 were the independent prognostic factors.Conclusion The expression of bcl-2 and Ki-67 were closely related with relapse after AHSCT in patients with ML. They were useful molecular makers for predicting the prognosis of patients with ML after AHSCT.
