Changes of resting-state default-mode network functional connectivity in patients with treatment-resistant depression

VernacularTitle:难治性抑郁症患者静息状态默认网络的改变
Author: Lingdi QIN ; Yan ZHOU ; Jun CHEN ; Jiong ZHU ; Jing TAO ; Lijun QIAN ; Jianrong XU
Publication Type:Journal Article
Keywords: Depression; Default-mode network; Functional connectivity; Posterior cingulate cortex
From: Chinese Journal of Medical Imaging Technology 2009;25(12):2182-2185
CountryChina
Language:Chinese
Abstract: Objective To explore the difference of resting-state default-mode network functional connectivity in patients with treatment-resistant depression (TRD) and in healthy subjects. Methods Ten patients with TRD and 12 healthy control subjects underwent 440 s fMRI scans while resting quietly. Functional connectivity analysis was used to isolate the default mode network in each subject. Group maps of the default-mode network were generated and compared between the two groups. A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on network functional connectivity. Results Functional connectivity of both side of middle temporal gyrus, rectal gyrus, precuneus gray matter, left orbital gyrus, right inferior parietal lobule, and post cingulate gyrus in TRD group weakened compared with that of the control subjects. Conclusion There are resting default network connection weakening in multiple brain areas in TRD patients, which may lead to self-control and emotional behavior abnormal in patients.