Observation on Prognosis in Patients with Multiple Organ Dysfunction Syndromes after Continuous Renal Replacement Therapy

VernacularTitle:连续性肾替代治疗对多脏器功能障碍综合征患者预后的影响
Author: Lihua WANG ; Fang WEI ; Aili JIANG ; Zhe WANG ; Haibo YU ; Haiyan CHEN
Publication Type:Journal Article
Keywords: renal replacement therapy multiple organ failure prognosis inflammatory mediators
From: Tianjin Medical Journal 2009;37(12):1011-1013
CountryChina
Language:Chinese
Abstract: Objective: To observe the prognosis of continuous renal replacement therapy (CRRT) in patients with multiple organ dysfunction syndrome(MODS). Methods: Thirty patients with MODS were enrolled in this study and were divided into two groups (survival group and death group) by their outcomes. All of these patients underwent CRRT for at least 24 h. The levels of interleukin (IL)-1β, IL-4, IL-6, IL-10 and tumor necrosis factor(TNF)-α were measured at the beginning and 3, 6,12 and 24 h after initiation of CRRT. Results: Among these thirty patients, the level of TNF-α came to peak at 12 h, and there was no significant difference between beginning and the end of CRRT. The level of IL-6 in death group was higher than that in survival group. There were correlations among numbers of complications, abnormalities of co-agulation and acute pathologic and chronic health evaluation Ⅱ(APACHEⅡ) separately. Conclusion: Clinical oxygenation and hemodynamics situation can be improved by CRRT, but there were no significant differences in levels of inflammatory mediators between initiation and the end of CRRT.