Study on the relationship between the grouping criterion of SWOG/ECOG and the prognosis of acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2010.01.006
- VernacularTitle:美国西南肿瘤组/东部肿瘤协作组染色体核型分组法与急性髓系白血病预后关系的研究
- Author:
Liang MA
;
Minghua ZHONG
;
Junxian LIAO
;
Jun SHEN
;
Hong LONG
;
Yanrong CHEN
;
Yiga MA
- Publication Type:Journal Article
- Keywords:
Leukemia,myelocytic,acute;
Chromosomes;
Cytogenetics;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2010;19(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence and distribution of aberrational karyotype in acute myeloid leukemia (AML), and study the significance of the grouping by Southwest Oncology Group/Eastern Cooperative Oncology Group (SWOG/ECOG) in the prognosis of AML Methods The chromosome was prepared with brief culture of bone marrow, and the karyotype was analysed by G banding technique. All the patients were grouped according to the criterion of SWOG/ECOG, and the survival function of different groups was observed by the Kaplan-Meier method.Results 56 (67.47 %) out of 83 patients had clonal chromosome aberrations. Among those 56 patients, AML with translocation (15;17) and with translocation (8;21) presented in 30 patients(53.57 %), and the other kinds of aberrational karyotypes shared the left proportion. Among the 74 followed-up patients, 42 patients were dead. Among three groups with favorable, intermediate and adverse prognosis respectively, there is a significant difference (P <0.001). The complete remission rate of favorable group is higher than that of both intermediate and adverse (P <0.05). There is no difference between intermediate and adverse groups(P>0.05). Conclusion Cytogenetic aberration is one of the important factors affecting the effect on prognosis. The criterion of SWOG/ECOG can predict prognosis objectively.
