Efficacy and safety of L-asparaginasum plus DICE regimen in the treatment of relapsed and refractory non-Hodgkin's lymphoma

VernacularTitle:左旋门冬酰胺酶联合DICE方案治疗复发难治性非霍奇金淋巴瘤的疗效和安全性
Author: Pu XIANG ; Yufu LI ; Jian ZHOU ; Jianwei DU ; Weiquan LU ; Baijun FANG
Publication Type:Journal Article
Keywords: Lymphoma,non-Hodgkin; L-asparaginasum; Recur ence refractory diseases
From: Journal of Leukemia & Lymphoma 2012;21(5):261-263
CountryChina
Language:Chinese
Abstract: Objective To observe the efficacy and adverse events of L-asparaginasum plus DICE regimen in the treatment of relapsed and refractory non-Hodgkin's lymphoma (NHL). Methods Thirty-one patients with relapsed and refractory NHL were treated with L-asparaginasum plus DICE regimen. Each patient was scheduled to receive 2 to 6 cycles.Results Among the 31 assessable patients,11 (35.5 ％) achieved a complete remission (CR),14(45.2 ％) got a partial remission (PR),2 were stable,4 were progressive.The overall response (CR + PR) rate was 80.7 ％.The median survival was 8 months (rang:2-38 months).The 1-year survival rate was 43.3 ％,the 2-year survival rate was 32.5 ％.The main adverse events were myelosuppression,digestive tract reaction,allergy and edema.No treatment-related death was observed.Conclusion The L-asparaginasum plus DICE regimen is effective and safe for the relapsed and refractory NHL.