Dual-energy CT lung perfusion imaging and perfusion scintigraphy in rabbit models of acute peripheral pulmonary embolism
- VernacularTitle:家兔急性肺栓塞模型双源CT双能量肺灌注成像与核素肺灌注显像
- Author:
Xue CHAI
;
Longjiang ZHANG
;
Yuxiao HU
;
Yane ZHAO
;
Yangbo XUE
;
Xiaobo HU
;
Hong ZHU
;
Guangming LU
- Publication Type:Journal Article
- Keywords:
Dual energy;
Perfusion imaging;
Pulmonary embolism;
Radionuclide imaging;
Models,animal
- From:Chinese Journal of Medical Imaging Technology
2010;26(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of dual-energy CT lung perfusion imaging and perfusion scintigraphy in acute pulmonary embolism (PE) rabbit models. Methods Acute PE models were established in 20 rabbits with femoral vein injection of sponge as embolus materials, and 4 rabbits were injected saline as control group. Two hours after embolization, dual-energy CT and perfusion scintigraphy imaging were performed respectively. Taking the pathologicall findings as the reference standards, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of both imaging methods were compared. CT values and enhancement degree (overlay value) of the embolic areas and normal pulmonary parenchyma were measured in DEPI image after embolization. Results Normal lung was color-coded as homogeneously yellowish red, perfusion scintigraphy displayed rarefaction or absence. The sensitivity, specificity, PPV, NPV of DEPI was 100%, 97.50%, 95.24%, 100%, and of perfusion scintigraphy was 67.50%, 81.25%, 64.29%, 83.33%, respectively. Increased CT values and overlay values of embolism areas in DEPI images were lower than those of normal pulmonary parenchyma (P<0.05). Conclusion DEPI has higher sensitivity and specificity than perfusion scintigraphy for detection of pulmonary emboli in an acute PE rabbit models.
