Umbilical cord blood neural stem cells for obsolete spinal cord injury
10.3969/j.issn.2095-4344.2014.41.021
- VernacularTitle:脐血源神经干细胞移植治疗陈旧性脊髓损伤
- Author:
Yuekui WU
;
Shangwu WANG
;
Jianhua MA
;
Bo YI
;
Bingbing GAO
;
Jiazhen QIN
;
Zhijun YANG
;
Yiwu DAI
- Publication Type:Journal Article
- Keywords:
spinal cord injuries;
neural stem cells;
fetal blood;
treatment outcome
- From:
Chinese Journal of Tissue Engineering Research
2014;(41):6678-6683
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:With the medical development, prognostic outcomes of spinal cord injuries have not been improved significantly, and most patients also suffer from severe complications. Nowadays, lots of laboratories and clinical researches have suggested that celltherapy has a great potential, especial y the application of umbilical cord blood stem cells in nervous system diseases. OBJECTIVE:To explore the feasibility and clinical effect of umbilical cord blood neural stem cells transplantation for patients with obsolete spinal cord injury. METHODS:Umbilical cord blood was harvested from newborns under aseptic condition, and differentiated into neural stem cells in vitro that were prepared into cellsuspension at a concentration of 109/L. The cellsuspension (3 mL) was injected via the L 3-4 or L 4-5 into the subarachnoid space. American Spinal Injury Association (ASIA) scores and the residual urine were assessed before and 3 months after transplantation. RESULTS AND CONCLUSION:After transplantation, al the patients showed a stable life indication. Three months later, ASIA scores were increased and the residual urine decreased, which significantly differed from those before transplantation (P<0.05). These findings indicate that umbilical cord blood neural stem cells transplantation is a new treatment that can improve the limb function and life quality of patients with obsolete spinal cord injury.
