Expression and clinical significance of cyclooxygenase-2 in multiple myeloma

VernacularTitle:环氧合酶-2在多发性骨髓瘤中的表达及其临床意义
Author: Ying HU ; Shilun CHEN ; Xiaonan HUANG ; Na AN
Publication Type:Journal Article
Keywords: Multiple myeloma; Cyclooxygenase-2; Proliferating cell nuclear antigen; Heat shock proteins 70; Immunohistochemistry
From: Journal of Leukemia & Lymphoma 2008;17(5):337-339
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of COX-2 in multiple myeloma(MM)and the relationship between myeloma cells proliferation and apoptosis.To provide a new prognosis factor and therapeutic target.Methods COX-2 from the 22 newly diagnosed MM,14 relapsed MM and PCNA,HSP70 of the newly diagnosed patients were detected by immunohistochemistry method.Results All the newly diagnosed MM exhibited positive COX-2 immunoreactivity.50% had strong COX-2 and 50% showed weak COX-2.Relapsed MM exhibited strong COX-2.COX-2 was related with serum β2 microglobulin,marrow plasma cells,hemoglobin,PCNA,HSP70(P=0.019,0.003,0.048,0.006,0.034).Conclusion COX-2 was overexpressed in MM.Prognosis of patients with strong COX-2 is poorer than those with weak COX-2.COX-2 may promote the proliferation and inhibit the apoptosis of myeloma cells.