Retrospective analysis of donor lymphocyte infusion for preventing relapse of leukemia after haplotype hematopoietic stem cell transplantation

VernacularTitle:供者淋巴细胞输注预防单倍型造血干细胞移植后白血病复发的回顾性分析
Author: Yuan ZHANG ; Xiaodong LIU ; Xuepeng HE ; Zhi GUO ; Jinxing LOU ; Kai YANG ; Peng CHEN ; Dan LIU ; Huiren CHEN
Publication Type:Journal Article
Keywords: Leukemia; Lymphocyte transfusion; Hematopoietic stem cell transplantation; Recurrence
From: Journal of Leukemia & Lymphoma 2011;20(1):26-28
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of donor lymphocyte infusion (DLI) for preventing relapse of leukemia after haplotype hematopoietic stem cell transplantation (HSCT), and evaluate the therapeutic effect and the safety of DLI. Methods The 20 haplotype HSCT patients who received DLI were studied for the occurrence of graft-versus-host disease (GVHD) and long-term survival. Results Eleven of twenty patients survived leukemia-free for a median of 25(4-60) months, and leukemia-free survival rate was 55 %. 9 cases died of relapse. 19 patients occurred acute GEHD (aGVHD) after received DLI, 4 of them were severe.Conclusion The prophylactic DLI is effective for preventing from relapse of leukemia. It might be feasible option.