Perspective research of preliminarily diagnosed angioimmunoblastic T-cell lymphoma with dose-adjusted EPOCH regimen
10.3969/j.issn.1000-8179.20141496
- VernacularTitle:剂量调整的EPOCH方案治疗初治血管免疫母T细胞淋巴瘤的前瞻性研究
- Author:
Kaili ZHONG
;
Hang SU
;
Xiubin XIAO
;
Jing LIU
;
Yun LU
;
Xilin CHEN
;
Yong DA
;
Chunlei LU
;
Weijing ZHANG
- Publication Type:Journal Article
- Keywords:
angioimmunoblastic T-cell lymphoma;
EPOCH regimen;
initial treatment;
chemotherapy
- From:
Chinese Journal of Clinical Oncology
2014;(19):1229-1233
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The effect and side effect of the dose-adjusted EPOCH regimen were evaluated perspectively for the pre-liminarily diagnosed angioimmunoblastic T-cell lymphoma. Methods: Nine cases of untreated angioimmunoblastic T-cell lymphoma were diagnosed and enrolled in our department from September 2008 to September 2012. All patients received dose-adjusted EPOCH regimen as first-line chemotherapy. Results: The median age of 9 patients was 54 years. The male-to-female ratio was 2∶1. About 88.9%of all patients were at Ann Arbor stageⅢ/Ⅳ, and 77.8%presented with B symptoms. Anemia was found in 66.7%of 9 patients, and lactate dehydrogenase elevated in 55.6%of patients. After an average of 4.7 cycles of chemotherapy of dose-adjusted EPOCH regi-men, the complete remission rate was 22.2%, and the total response rate was 66.7%. With a median follow-up of 20 months, the 4-year progression-free survival rate was 11.1%, and the overall survival rate was 33.3%. The median survival time was 19 months. The most common adverse events of EPOCH chemotherapy were hematologic toxicity. Grades 3-4 neutropenia and thrombocytopenia were re-ported in 77.8%and 33.3%of patients. Febrile neutropenia was observed in 44.4%of patients. Non-treatment-related mortality was al-so noted. Conclusion: The results of our research showed no clear benefit of treating preliminarily diagnosed angioimmunoblastic T-cell lymphoma with dose-adjusted EPOCH regimen. The main adverse events were hematologic toxicity and could be tolerated.