Study on Cut-Off Value with D-Dimer Testing for Diagnosis by Exclusion of Venous Thromboembolism in Patients of Different Ages
10.3969/j.issn.0253-9896.2014.01.006
- VernacularTitle:不同年龄患者D-二聚体排除诊断静脉血栓临界值的研究
- Author:
Jing REN
;
Gang LI
;
Bowei ZHANG
;
Yanxue ZHANG
- Publication Type:Journal Article
- Keywords:
D-dimer;
venous thromboembolism;
aged;
rule out;
cut-off value;
age
- From:
Tianjin Medical Journal
2014;(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma level of D-dimer in healthy population and hospitalized patients, and to analyze the cut-off value of D-dimer levels in different age groups for the exclusion of venous thromboembolism (VTE) in older patients. Methods A total of 6 717 healthy individuals and 2 976 hospitalized patients were included in the study. The blood level of D-dimer was detected by the Biomerieux VIDAS fluor-euzymelinked immunoassay analyzer assay. Results The blood level of D-dimer was significantly increased with age in healthy people aged over 40 and different age groups of hospitalized patients (P<0.01). The incidence of venous thromboembolism was also increased with age. The cut-off value for the diagnosis of VTE with D-dimer was 504 μg/L in patient group aged ≤40 years, and the sensitivity was 100.0%. The cut-off value was 565μg/L in 41~60-year group, and the sensitivity was 96.2%. The cut-off value was 817μg/L in 61~74-year group, and the sensitivity was 80.8%. The cut-off value was 1 024μg/L in≥75-year group, and the sensitivity was 73.1%. Conclusion The plasma D-dimer level increased with age. The D-dimer cur-off value was higher in older patients than that of other age groups, but the sensitivity in diagnosis was decreased obviously.
