Expression level of VEGF in NHL and its clinical significance

VernacularTitle:血管内皮细胞生长因子在非霍奇金淋巴瘤中的表达及其临床意义
Author: Songmei YIN ; Yiqing LI ; Shuangfen XIE ; Danian NIE ; Liping MA ; Xiuju WANG ; Yudan WU
Publication Type:Journal Article
Keywords: Lympboma,non-Hodgkin's; Vascular endothelial growth factors; Prognosis
From: Journal of Leukemia & Lymphoma 2009;18(1):23-25
CountryChina
Language:Chinese
Abstract: Objective To detect the expression of VEGF in NHL and analyze the relation of the expression levels with malignant aggressiveness,treatment response,and prognosis.Methods The expression of VEGF in lymph nodes taken from 39 NHL patients Wag measured by immunohistochemical-staining method.9 patients with benign lymphadenopathy were acted as control.Results The expression of VEGF in NHL(79.5%)was higher than that in the contrel(44.4%)(P=0.048＜0.05).In NHL,the VEGF level was higher in aggressive lympboma than that in indolent lymphoma(x2=5.284,P=0.044＜0.05).The patients had the higher-level expression as the Ann Arbor stage Wag higher,and the patients who had the higher-level expression of VEGF had higher serum LDH level,lower chemotherapy remission,unfavorable prognosis and lower 3-year survival (P＜0.05).Conclusion The expression of VEGF in NHL was increased.It was correlated with histopathological grade,Ann Arbor stage,chemotherapy response and prognosis.