Severe pulmonary complication after bortezomib treatment for multiple myeloma: two cases report with literature review

VernacularTitle:硼替佐米治疗多发性骨髓瘤后严重肺损伤二例报告并文献复习
Author: Yafei WANG ; Lugui QIU ; Dehui ZOU ; Ying WANG ; Shuhui DENG ; Yuan LI ; Yan XU ; Linsheng QIAN ; Yaozhong ZHAO
Publication Type:Journal Article
Keywords: Multiple myeloma; Respiratory distress syndrome,adult; Bortezomib
From: Journal of Leukemia & Lymphoma 2008;17(2):100-102
CountryChina
Language:Chinese
Abstract: Objective To report two cases of severe pulmonary complication after bortezomib treatment for multiple myeloma. Methods Two cases of severe pulmonary complication after bortezomib treatment patients with relapsed multiple myeloma wereas discussed with review of literature. Results Two relapsed MM patients were treated with bortezomib and thalidomide or dexametbasone. Cough, dyspnea, fever and hypoxia developed after completion of bortezomib. Chest X-ray revealed bilateral pulmonary infiltrates,but infection was not identified with sputum cultures, and broad-spectrum antibiotics were ineffective.Conclusion Severe pulmonary injury was rare complication in patients receiving treatment for multiple myeloma, however, it was a life-threatening disorder. Prophylaxis corticosteroids maybe effective. Although corticosteroids are effective, but the mechanism of lung injury associated with bortezomib is unclear, and further evaluation of this potential toxicity is appropriate.