Allogeneic peripheral blood stem cell transplantation combined with bone marrow transplantation for malignant hematologic diseases
10.3760/cma.j.issn.1009-9921.2009.11.006
- VernacularTitle:异基因外周血造血干细胞移植联合骨髓移植治疗白血病30例
- Author:
Xinsheng XIE
;
Dingming WAN
;
Hui SUN
;
Ling SUN
;
Linxiang LIU
;
Guiju WANG
;
Zhongxing JIANG
;
Shaoqian CHEN
;
Yuandong CHENG
;
Shaojun LIU
;
Dianbin ZOU
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem ceil;
Peripheral blood;
Bone merrow;
Leukemia
- From:
Journal of Leukemia & Lymphoma
2009;18(11):657-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe curative effect and clinical outcome in 30 recipients undergoing allogcneic peripheral blood stem cell transplantation (PBSCT) combined with bone marrow transplantation (BMT). Methods 30 patients with a median age of 32.6 years underwent allo-HSCT, of which 11 patients with AML, 14 patients with ALL, and 5 patients with CML They all have a HLA-identical sibling. PBSCswere mobilized with G-CSF. Three hundreds milliliter bone marrow blood was transplanted to the patients on the day that the PBSC was transplanted. Amended Bu/Cy was used as the conditioning regimen. MTXcombined with CsA and MMF was used as GVHD prophylaxis. Results A median number of mononuclear cells of (5.13±2.6)x10~8/kg recipient's weight was collccted from peripheral blood, and (1.3±0.6)x10~8/kgrecipient' s weight from bone marrow blood. Engraftment of neutrophils and platelets was achieved at a median of (12.1±3.25) days and (14±5.33) clays respectively. Ⅰ - Ⅱ acute GVHD occurred in 40.0 % cases,Ⅲ - Ⅳ acute GVHD occurred in 3.3 % cases, and chronic GVHD developed in 43.3 % cases. Severe cGVHD developed in 3.3% cases. The 2 years disease free survival rate (DFS) by the day of transplantation was 72.0 %. Conclusion PBSCT combined with BMT was effective to cure leukemia. The results also suggested that PBSC recipients had an lower incidence of aGVHD and cGVHD as compared with previous reports.
