Nodal marginal zone B-cell lymphoma with monocional IgM:2 cases report and review of literatures
10.3760/cma.j.issn.1009-9921.2009.03.012
- VernacularTitle:结内边缘带B细胞淋巴瘤伴有单克隆IgM增高两例并文献复习
- Author:
Huan WANG
;
Xiaoge ZHOU
;
Mei XIONG
;
Zhao WANG
- Publication Type:Journal Article
- Keywords:
Lymphoma,B-cell,nodal;
IgM
- From:
Journal of Leukemia & Lymphoma
2009;18(3):160-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the clinical and pathological features, diagnosis, treatment and prognosis of nodal marginal zone B-cell lymphoma (NMZL). Methods 2 patients, with NMZL who has extremely elevated monoclonal IgM were analyzed and review were included. Results The common pathological diagnosis caused by the association of monoclonal gammopathy with indolent B-cell non-Hodgkin lymphomas was marginal zone lymphoma or B small cell lymphocytic lymphoma/B-cell chronic lymphocytic leukemia. According to our cases and literatures, the main distribution of involved sites in NMZL were lymph nodes, spleen and bone marrow. Sixty percent of the NMZL patients presented with advanced stage with, high risk of IPI. The diagnosis of NMZL was based on pathology of the lymph node. The proliferation and distribution of the differentiation monocytoid cell had a specified significance. Prognosis of early stage ( I or Ⅱ) NMZL were much better than that of advanced stage NMZL even the patients had received chemotherapy.Conclusion NMZL mainly involved lymph nodes, bone marrow and spleen, sporadically associated with the elevated monoclonal IgM. Most of the NMZL patients presented with advanced stage.The prognoses were poor.
