Prospective study of multiparmeter flow cytometry for monitoring the treatment effect of acute leukemia
10.3760/cma.j.issn.1009-9921.2012.05.011
- VernacularTitle:多参数流式细胞术对急性白血病治疗效果监测的前瞻性研究
- Author:
Yan ZHANG
;
Liping TIAN
;
Wei ZHANG
;
Xiaoming QIN
- Publication Type:Journal Article
- Keywords:
Multiparameter flow cytometry;
Leukemia,acute
- From:
Journal of Leukemia & Lymphoma
2012;21(5):294-296
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo monitor the treatment effect of acute leukemia by multiparmeter flow cytomtry(MPFC), MethodsThe patientswith acute leukemia all achieved complete remission after remission induction therapy.Before the chemotherapy,the bone marrow cell morphology and MPFC inspection were used for each patient. Through statistical analysis, the relationship between morphological feature andrecurrence,as well as time duration till recurrence were obersved. ResultsThe 122 specimens from 30 patients were observed.The specimens were analyzed by morphological examination of bone marrow cells,and the other 61 specimen through MPFC. There were 8 positive specimen(13.11％)through morphological examination,while 18 positive specimen(29.51％ )through MPFC. There was a significant difference between the two groupes by x2 test (x2=4.33,P＜0.05).The 18 MPFC-positive specimens were from 10 patients.In the follow-up period, there were 6 patients whose morphological examination also prompted the recurrence in 1-4 months. Three patients were failed to follow up because of 2 patients became negative and 1 patient died. ConclusionMPFC is more sensitive and able to assess the effect of acute leukemia treatment more objectively and detect the recurrence earlier than morphological examination.
