The effect of hematopoietic stem cell transplantation on myelodysplastic syndrome

VernacularTitle:干细胞移植治疗骨髓增生异常综合征13例
Author: Qian ZHANG ; Hai BAI ; Xiping FAN ; Cunbang WANG ; Rui XI ; Yaqin LING
Publication Type:Journal Article
Keywords: Myelodysplastic syndromes; Hemopoietic stem cell transplantion; Allogeneic
From: Journal of Leukemia & Lymphoma 2010;19(9):533-535
CountryChina
Language:Chinese
Abstract: Objective To investigate the curative effect of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the method of the pretreatment choice on myelodysplastic syndrome (MDS).Methods 13 cases who were undergoing allo-HSCT including 10 HLA-matched, 2 HLA partially matched,and one umbilical cord blood transplanted patients were enrolled in this study. The infusion number of MNC and CD+34 cells is 6.92 (2.65-21.33)×108/kg and 4.47 (1.49-10.22) ×106/kg, respectively. Of the 13 cases,5 adopted TBI, fludarabine(Flud), and cyclophosphamide(Cy) pretreatment, 3 chose BU/Cy pretreatment, and 3 chose TBI and Cy pretreatment, 2 chose Ara-C+BU+Cy+VM26 pretreatment. In order to prevent GVHD, 2cases of HLA partially matched were treated with ATG, cyclosporin A (CsA), MTX and MMF aftertransplantation, while the others were treated with CsA and MTX only. Results 9 out of 13 cases achieved hematopoietic reconstruction completely. 4 died of complications. Conclusion The allogeneic hematopoietic stem cell transplantation is an efficient regimen to cure MDS. The pretreatment should adopt the individuation.